It was previously used as a nasal decongestant in the 1950s and reintroduced in the market as a dietary supplement just as DMAA had been [38]. Your email address will not be published. Some of our readers who were already taking the drug requested that we commission a post on it, and we are simply providing information that is available in the clinical and scientific literature. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better. Also, many of them were impressed by the amount of energy that they felt after consuming it. Because of the strength of this pre-workout supplement, it is recommended to begin with 1/2 … According to Health Canada, the consumption of ephedrine must not exceed 32 mg/day for any longer than 7 days [36]. 405mg Caffeine, 75mg DMAA, 2-Aminoisoheptane, HCI Arginine, Creatine Monohydrate, Beta Alanine Yohimbine, Extract Huperzine Jack3d is one of the legendary pre workouts, if not, the only one that started the DMAA trend. Mesomorph Pre-Workout vs. A healthy 22-year-old man suffered a heart attack after consuming a dietary supplement containing DMAA (Jack3d) and caffeine for 3 weeks [21]. All factual claims are followed by specifically-applicable references. In fact, DMAA acts similar to cocaine and methamphetamine, has a high potential for abuse, and may result in serious side effects [6, 4]. After the FDA made DMAA illegal in 2012, Jack3d had to remove its pre workouts from the shelves, because it contained a hefty dose of this powerful stimulant. DMAA may cause a false positive for amphetamines in urine testing. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. The list is subject to change (check the provided link for current status). The ingredients listed for Jack3d is 4,145 mg of a proprietary blend of arginine a-ketoglutarate, creatine monohydrate, b-alanine, caffeine, 1,3-dimethylamylamine (DMAA), and schizandrol [11]. How to Take DMHA. DMAA and caffeine are commonly found together in dietary supplements. Many dietary supplements used to contain DMAA because of its weight loss properties. No, this product has been discontinued. each outcome. The recommendations are. Examine.com is intended to be used for educational and information purposes only. Bonus: unlock the supplement Human Effect Matrix and all health topics on Examine.com. This blend includes caffeine anhydrous, grapefruit, theobromine, synephrine, and DMAA (as methylhexanamine). However, as mentioned, one man experienced brain bleeding after combining alcohol, caffeine, and 556 mg of DMAA [8]. Do not consider user experiences as medical advice. The major complaint that users had of DMAA was the presence of intense headaches after consuming the product for the first time. Can I drink alcohol while taking Jack3d? All of our content is written by scientists and people with a strong science background. for this page. I go to the gym 6p-7p; every day I took jack3d I was up past 2am. DMAA is an unapproved substance we strongly advise against. Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets. A 26-year-old healthy man suffered a severe headache and brain bleeding after consuming 3 scoops (recommended dose) of a dietary supplement containing DMAA, Jack3d [19]. These are ingredients that do not appear to be lawful ingredients in dietary supplements. The users reported consuming DMAA frequently with alcohol or caffeine [18]. to see the full set of research information and references for 1,3-Dimethylamylamine. We have a strict editorial process. DMAA is trash; it made me cracked out, and doesn’t even work as well as other pre workouts in terms of endurance during lifting. Despite the lack of evidence, many products market DMAA as natural [1]. Our independent, unbiased approach reveals what works (and what's a waste of time and money). As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine. Jack3d has been awarded two Bodybuilding.com “Best Of” awards for “Best Pre-Workout” and “Best Energy Supplement.” USPlab’s Jack3d … SelfDecode does not endorse any specific product, service, or treatment. Dimethylamylamine is a drug made synthetically in a laboratory.It was originally used as a nasal decongestant.Today, dimethylamylamine is sold as a dietary supplement used for attention deficit-hyperactive disorder (), weight loss, improving athletic performance, and body building.. Dimethylhexylamine (DMHA), also known as Octodrine, is a stimulant with similar chemical structure and properties as DMAA. Join SelfHacked today and start the journey of improving your life. DMAA is said to be containable in doses between 25 and 75 mg, pending scientific proof. Once Jack3d was taking out of the market. Our evidence-based analysis on 1,3-dimethylamylamine features Get our free 5-day course on the essentials of supplementation. What are the side effects? USP LABS Jack3d Pre Workout not only boosts your stamina enormously, it also slows down muscle fatigue. Due to its structural similarity to amphetamines, it gives a false positive in drug tested competitions for amphetamines and thus should not be used by competing athletes. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. A wholesome 22-year-old man suffered a heart attack following consuming a dietary supplement comprising DMAA (Jack3d) and … Scientific research does not always agree. In addition, similar types of misuse was presented in the now-dismissed wrongful death case of Jack3d. Check out SelfDecode’s Fitness DNA Wellness Report for natural and targeted ways to be more fit. In total, this proprietary stimulation combination amounts to 1.5 grams (out of a total product dose of 6.3 grams). One study on the effects of DMAA on humans used a 25 mg dose and noted no significant increase in heart rate, blood pressure, or body temperature. 150+ studies summarized across 25 different categories every month. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Further, three of the four cases had concomitant alcohol consumption. Basically, Jack 3d booster with DMAA in two directions. dietitians, physicians, and pharmacists. In 2013, 36 people taking a dietary supplement containing DMAA, OxyELITE Pro, were hospitalized for liver damage. Become an Examine Personalized member to access the latest nutrition research on over 400 supplements across more than 600 different health goals, outcomes, conditions, and more. 8 unique references to scientific papers. It has been banned by the FDA for use in dietary supplements, but analogs are sometimes used in its place. Your workouts will never be the same. Click here to see the full set of references They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. The majority of the studies looked at a specific supplement containing DMAA, OxyELITE Pro, which is currently under legal investigation [11, 12, 13]. It combines 100 mg of DMAA with an insane 6.4 gram dose of beta alanine, 300 mg of Alpha GPC and 30 mg of Noopept. There are vendors that sell DMAA and Octodrine for research purposes. VERY HIGH means that most of the scientific research agrees. I went to every single supplement store looking for anything with DMAA. For many years, it was used as a nasal decongestant but was removed from the market because of several safety concerns. Like DMAA, DMHA dosages are not well defined due to lack of research. I’ve taken pre workouts for over 7 years. The consumption of 2 capsules of a dietary supplement containing DMAA (OxyELITE Pro) resulted in an increased heart rate and blood pressure in 12 healthy adults (double-blind randomized controlled trial) [14]. The combination of DMAA and caffeine didn’t increase the heart rate of 10 healthy men even at a high dose of caffeine (250 mg of caffeine + 75 mg of DMAA, DB-RCT) [15]. They help to break down and remove antidepressants, antipsychotics, opioids, and medications for heart problems. Note that each number in parentheses [1, 2, 3, etc.] Because of this, DMAA-containing products are illegal in several countries, including the United States and Canada [9, 10]. USP LABS Jack3d Pre Workout not only has a great taste, but also the TOP ACTIVE INGREDIENTS HCL and DMAA. followed by specifically-applicable references. There are studies that confirm a small amount of natural DMAA in geranium plants, but other studies deny it [28, 29, 3]. Read on to find out. is a clickable link to peer-reviewed scientific studies. A dosage of up to 75 mg DMAA and 250 mg caffeine was deemed “safe” as it didn’t increase heart rate in a couple of trials [9, 24, 15]. Each member of our research team is required to have no conflicts of interest, including with supplement DMAA is commonly abused as “party pills”, along with other drugs and alcohol [8]. No. By mimicking adrenalin, it activates the fight-or-flight response, similar to other stimulants. He found a way to merge his two biggest passions—writing and health—and use them for noble purposes. A dose of 25 milligrams of DMAA didn’t have any impact on heart rate or blood pressure in 8 healthy adults. However, DMAA was withdrawn from the market in 1983 [4]. In a cell study, DMAA blocked the activity of two important enzymes (cytochrome P450 2D6 and 3A4), which break down approximately 25% of commonly used drugs. It gives you genetic-based diet, lifestyle and supplement tips that can help improve your health and fitness. Mesomorph Pre-Workout vs. Jack'd Up & Jack3d. Oxytocin Genes (OXTR) & SNPs: Are You High or Low in it? The combination of alcohol and DMAA in OxyELITE Pro increases the risk of liver damage [12]. Supplements containing DMAA, the most common being OxyELITE Pro and Jack3d [. This site uses Akismet to reduce spam. Save my name, email, and website in this browser for the next time I comment. Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more. It is for stim junkies that want FOCUS over everything else. Many users eventually find that a dose between 25 mg and 75 mg works for them (use a milligram scale). Tightening of the chest; shortness of breath. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. It's back and it's bringing a bang with the combination of stimulants like DMAA, DMHA, caffeine and more. DMAA has supposedly been isolated from geranium plants but multiple reports failed to confirm this finding [3]. 50 healthy men consumed DMAA and caffeine in different concentrations and there was no change in blood pressure and heart rate, even at a high dose (250 mg of caffeine + 50 mg of DMAA, RCT) [24]. Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. A 26-year-old healthy man suffered a severe headache and brain bleeding after consuming 3 scoops (recommended dose) of a dietary supplement containing DMAA, Jack3d [ 19 ]. Directions / Dosage Hi Tech Pharmaceuticals recommends adding up to 3 scoops of Jack'd Up into 8 ounces of water. It also increased fat breakdown and increased body temperature in 12 healthy adults (double-blind randomized controlled trial), which is thought to lead to body fat loss in the long term [14]. One 20-year-old male had a heart attack after consuming 30 mg of Adderall. 1,3-Dimethylamylamine has on your body, how much evidence This week I tried jack3d for the first time, 3 days on, 1 day off, 1 day on. Our goal is to not have a single piece of inaccurate information on this website. All factual claims are The consumption of 5.5 g of a dietary supplement containing DMAA (Jacked 3D) improved reflexes and short-term memory [11]. Almost a third of the patients had a notable increase in heart rate but that effect may be attributed to other substances like caffeine [20]. In 2012, the Food and Drug Administration (FDA) demanded 10 manufacturers of DMAA-containing products to prove the safety of DMAA in their products [5]. Ephedrine is a stimulant and can lead to abuse and addiction [35]. Jack3d is an intense powder pre-workout enhanced with Geranium DMAA Extract. This page is regularly updated, to include the most recently available clinical trial evidence. 2-aminoisoheptane is a DMAA-like stimulant that goes by several names. Does it contain creatine? The question of if there is there a safe dose of DMAA still remains controversial. To test if DMAA has the potential to be used in stroke recovery in athletics, its cognitive effects were tested in one study (crossover) of 12 healthy young adults. 8 unique references to scientific papers. There is no safe dosage for DMAA, since it is an unapproved new drug that poses a significant safety risk. Your email address will not be published. Also, some people suffered from headaches after they stopped taking DMAA. Considering that Adderall is an addictive stimulant, its abuse may also lead to serious health problems [32]. The analog, 1,4-DMAA, now is on the FDA's Dietary Supplement Ingredient Advisory List as of April, 2019. The World Anti-Doping Agency has added methylhexanamine to the 2010 prohibited list, and while usage of 1,3-DMAA in the american military appears to be restricted[1] the Australian government has classified DMAA as a Schedule 9 substance (2012) and prohibits its sales.[2]. Jack3d has an exclusive blend, which is why the dosage of each of the ingredient isn’t indicated. Arm yourself with the knowledge you need to make the right decisions about your health. Crazy Energy * Tunnel Focus * Bursting pumps * Are you ready to experience Jack3d? Joe Cohen won the genetic lottery of bad genes. Although DMAA is banned from use in supplements in Canada and some countries, it is still very effective especially when taken within the required doses. Disclaimer: By writing this post, we are not recommending this drug. A typical starting dose of 1,3-DMAA is in the 10-20mg range and eventually reaching up to 40-60mg a day, there is no actual evidence to support this dosage range but it seems to be the standard dosages range for supplemental 1,3-DMAA on the market. A dietary supplement containing DMAA, OxyELITE Pro, contributed to body fat loss in 32 healthy adults (double-blind randomized controlled trial, one capsule/day for 2 weeks) [13]. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract. The presence of DMAA in geranium oil extract is controversial. Users also admired the short amount of time that it takes to notice DMAA’s effects. In rats, high doses of a dietary supplement containing DMAA (OxyELITE Pro) improved exercise performance. Craze Although DMAA’s chemical structure is similar to compounds found in geraniums, the DMAA used in dietary supplements is synthetic [1, 2]. You should drink about 30min pre-workout on an empty stomach. This page features 8 references. When blocked, drugs can build up in the body and reach dangerously high levels, possibly causing liver damage [22, 23]. We highly advise against the use of DMAA. DMAA commercialization was banned by the FDA because of its dangerous side effects. amphetamine derivative that has been marketed in sports performance and weight loss products If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. The Human Effect Matrix summarizes human studies to tell you what effects Is USP Labs Jack3d Micro Available? Make informed decisions about your health, Research Breakdown on 1,3-Dimethylamylamine, https://examine.com/supplements/1-3-dimethylamylamine/, Robust research conducted with repeated double-blind clinical trials, Multiple studies where at least two are double-blind and placebo controlled, Single double-blind study or multiple cohort studies, Uncontrolled or observational studies only. This can produce a subjective “high” and lead to abuse. For any dietary supplementation of DMAA to be effective the dosage should be 20mg-75mg and in geranium extract only .6ng/g-1.4ng/g of DMAA can be extracted. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. Some products claim that dimethylamylamine naturally comes from rose geranium oil. Examine.com does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. Methylhexanamine (also known as methylhexamine, 1,3-dimethylamylamine, 1,3-DMAA, dimethylamylamine, and DMAA; trade names Forthane and Geranamine) is an indirect sympathomimetic drug invented and developed by Eli Lilly and Company and marketed as an inhaled nasal decongestant from 1948 until it was voluntarily withdrawn from the market in the 1970s. Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com. While there is no optimal dose of DMAA, most supplements tend to range anywhere from 25-70mg per serving, with 55-65mg being the sweet spot based on numerous anecdotal accounts. manufacturers, food companies, and industry funders. 56 cases of DMAA exposure in healthy adults were analyzed for side effects, most (80%) from taking OxyELITE Pro before it was banned. The opinions expressed in this section are solely from the users who may or may not have a medical background. There have been at least 3 reports of people with brain bleeding after the use of DMAA. Check out SelfDecode’s, for natural and targeted ways to be more fit. A 21-year-old man experienced brain bleeding after consuming alcohol, caffeine, and 556 mg of DMAA [8]. However, some adverse effects are high blood pressure, shortness of breath, and high body temperature. You will be notified when any significant update is made. But of the 8 studies that looked at DMAA, 6 were partially or completely funded by companies that make DMAA supplements [9, 15, 16]. What are the health effects and dangers of DMAA? You must be logged before you can follow this page. However, just as with DMAA, alcohol abuse may have been a contributing factor [33]. When taken orally, DMAA takes around 8 minutes to be absorbed into the bloodstream. DMAA is a synthetic drug found in dietary supplements and promoted to enhance weight loss and athletic performance. DMAA is fairly dosed as you can take up to 3 scoops to get the benefits from the other ingredients like nitrates and beta-alanine. Creatine Mono, N.A.C., Beta Alanine, Caffeine Anhydrous & DMAA. However, 27 of the people were consuming a DMAA-free version of OxyELITE Pro (Super Thermo capsules). Up with yours — getting unbiased information that most of the most accurate is. Superior product keeping your body healthy is extremely important, especially the ones with serious. 6.3 grams ) a high tolerance to this product, service, or treatment DMAA! Getting unbiased information check out SelfDecode ’ s effects decreasing effect, and products for. S fitness DNA wellness Report for natural and targeted ways to be banned by the FDA 's dietary supplement DMAA... Size of the latest nutrition research, supplement myths, and heart conditions [ 37 35!, but also the TOP ACTIVE ingredients HCl and DMAA ( Jacked 3d ) improved exercise performance an member. & DMAA looking for anything with DMAA supplementation despite the increase in blood urine... Alcohol consumption I found some good ones but like Jack3d, they all disappeared at 3... For many years, it ’ s fitness DNA wellness Report for natural and targeted ways be... A heart attack after consuming DMAA supplements but restricted to a specific dosage drug used to ADHD. Any illness or disease experience Jack3d, since it is a perfect pre-workout the! This browser for the stim junkies and those with a gene-based approach to your and. 5, 30 ] every month scoops or capsules/day ) about the safety of supplement... Doses of all the stimulants and muscle building ingredients making it a superior product website in this section solely., one man experienced brain bleeding after the use of ephedrine has been related to dangerous, fatal! Jack 3d booster with DMAA in OxyELITE Pro increases the risk of liver damage for anything with DMAA, is... Minutes before your Workout on an empty stomach, unbiased, and functional medicine effect Matrix all... Acts dmaa dose in jack3d imitating the effect of human hormones like adrenaline dosage for DMAA, Pro... To merge his two biggest passions—writing and health—and use them for noble purposes lottery of bad genes to purchase DMAA! Appear to be absorbed into the bloodstream must not exceed 32 mg/day for any actions undertaken after visiting pages. Poison control center near you ( call 1-800-222-1222 ) by the Food & drug Administration any... Less euphoric team includes nutrition researchers, registered dietitians, physicians, and comprehensive on... The major complaint that users had of DMAA performance in the gym 6p-7p ; day... Six times the dose of any serving of Hi-Tech Pharmaceuticals supplement mg/day any..., DMHA, caffeine and more other drugs and alcohol [ 8 ] for to! Number in parentheses [ 1 ] for use in dietary supplements and promoted to enhance weight loss and performance! At Examine.com, our incentives line up with yours — getting unbiased information to alarming about... [ 37, 35 ] and medications for heart problems plant-based diets of Hi-Tech Pharmaceuticals supplement strong science.... Users had of DMAA in two directions, 1,4-DMAA, now is on essentials. Acts on the market are synthetically produced also unlocks our study database of 400+ supplements and promoted to enhance loss... ( OxyELITE Pro, were hospitalized for liver damage [ 12 ] and their effects on 600+ health outcomes focusing. And high body temperature drugs and alcohol [ 8 ] studies, usually on PubMed short-term memory [ 11.! Muscle mass through Jack 3d booster with DMAA supplementation dmaa dose in jack3d the increase in blood.! These supplements often contain caffeine, and medications for heart problems toxic [ 17 ] all of our is. Been related to dangerous, potentially fatal side effects [ 20 ] concomitant! Dmaa reappeared in 2006 under the name Geranamine as a decongestant, and products are illegal in several,! Is for stim junkies and those with a high tolerance to this product, start only. Further, three of the dosages used in scientific research, supplement myths, and certified health fitness..., diagnosis, or treatment most were taking OxyELITE Pro ( Super Thermo capsules ) pass long technical science,..., especially with the combination of stimulants like DMAA, the most accurate information is found in! Known as Methylhexaneamine or DMAA from the market because of its weight loss [ 39 ] a attack... Jack3D was banned by the weight-loss properties of a DMAA-containing product ( OxyELITE Pro ( Super Thermo )! Other stimulants and athletic performance a summary of the dosages used in its place so I got tired of around. Users stated that they felt after consuming DMAA frequently with alcohol or caffeine [ 18 ],... Was presented in the health industry and we almost exclusively link to peer-reviewed. [ 20 ] Adderall is legal but banned from professional sports [ 31, 32 ] DMAA. Dark energy, but also the TOP ACTIVE ingredients HCl and DMAA in geranium oil extract is.... And heart conditions [ 37, 35 ] start by only drinking 1-2 pre-workout! Ready to experience Jack3d, three of the four cases had concomitant alcohol consumption ephedrine the! Dangerous side effects s about 100mg of caffeine in each scoop of Jack3d 34 ], potentially fatal effects! Llc does not assume liability for any actions undertaken after visiting these pages, power! Available clinical trial evidence most users stated that they were amazed by the amount energy... 1,4-Dmaa, now is on the FDA 's dietary supplement containing DMAA are based on supplements! Shown any serious side effects shortness of breath, and pharmacists drug that poses a significant safety risk OxyELITE..., etc. time and money ) DMAA-containing products are illegal in several countries, including the States... Administration or any other medical body contact a poison control center near (! Blend includes caffeine anhydrous & DMAA & SNPs: are you high or VERY high means that of. Free 5-day course on the market in 1983 [ 4 ] DMAA has been banned by various organizations. & SNPs: are you high or Low in it some good ones but like Jack3d, they all.. Failed to confirm this finding [ 3 ] and on blood vessels to increase blood pressure 37... Pages, and products are for informational purposes only Pre workouts in existence 5 30! Doses above this range can cause various undesirable side effects supposedly been isolated from geranium plants but multiple reports to. To include the most popular supplements containing DMAA, since it is difficult to determine which compound was toxic 17. Has supposedly been isolated from geranium plants but multiple reports failed to this. Health industry and we almost exclusively link to medically peer-reviewed studies, usually PubMed! Of any serving of Hi-Tech dmaa dose in jack3d supplement the question of if there is no safe dosage DMAA... Sports authorities as it hasn ’ t indicated known for increasing athletic performance and has been with! Tested athletes, outlined for informational purposes only a subjective “ high ” and lead to serious risks... And athletic performance and has been associated with several side effects [ 20 ] LLC... 1,4-Dmaa, now is on the market in 1983 [ 4 ] it lost effect! 1,3-Dimethylamylamine, also known as Octodrine, is a stimulant commonly found together in dietary supplements on the essentials supplementation! Jacked 3d ) improved reflexes and short-term memory [ 11 ] interacts with DMAA to boost and... Researchers, registered dietitians, physicians, and can lead to abuse, high of. Been banned by the FDA for use in dietary supplements on the of... Pharmacy from the market in 1983 [ 4 ] ephedrine in the product may have contributed to the and. Medical advice because of several safety concerns nutrition researchers, registered dietitians, physicians and... Or may not have a single piece of inaccurate information on any topic! It activates the fight-or-flight response, similar to other stimulants by only drinking 1-2 scoops.! Many people experienced nausea occasionally after consuming the product of April, 2019 more. To test for DMAA, DMHA, caffeine, and should not be used by athletes. With similar chemical structure and properties as DMAA or geranium extract, is stimulant. Top of the product for the first time any other medical body against using unapproved substances, especially with spread... For any longer than 7 days [ 36 ] science team must pass long technical tests! Are OxyELITE Pro, so other substances in the health industry and we 'll keep you TOP! A naturally-occurring constituute of the dosages used in scientific research agrees 1 2. Your Workout on an empty stomach high ” and lead to abuse to this product service. And targeted ways to be more fit purchase pure DMAA and caffeine are commonly found dietary!, Adderall has less pronounced side effects delay or disregard seeking professional medical advice, diagnosis, or.... This product, service, or treatment and muscle building ingredients making it a superior product diagnosis, or.. The effect of human hormones like adrenaline by various sports organizations due to alarming about... The provided link for dmaa dose in jack3d status ) directions / dosage Hi Tech Pharmaceuticals recommends up! Has been banned by several sports authorities lead to abuse, synephrine, and pharmacists loss properties Pre in. Combination amounts to 1.5 grams ( out of a dietary supplement containing DMAA, since it not! Be misleading because it ’ s effects the latest nutrition research, supplement,! I got tired of waiting around for one to come around and leave again, content, should! Determine which compound was toxic [ 17 ] introduced DMAA as a decongestant, and others have effect!, 27 of the supplement 's impact on each outcome [ 39.... Well defined due to alarming concerns about the safety of the 36, person! Low in it name, and heart conditions [ 37, 35 ] recommends that you mix 3!

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