Glycols related to and coproduced with diethylene glycol and have the formula HOCH2CH2(OCH2CH2)nOH are: These compounds are all hydrophilic, more so than most diols, by virtue of the ether functionality. Notice of Adoption to Text of Regulations Title 22, Amendment to Section 12805 Maximum Allowable Dose Levels (MADLs) for Ethylene Glycol Monoethyl Ether (EGEE), Ethylene Glycol Monoethyl Ether Acetate (EGEEA), and Potassium Dimethyldithiocarbamate Diethylene glycol monobutyl ether is used as a solvent in paints and varnishes e.g. Investigations revealed that all had taken a medicine called “My Pikin Baby”, a teething mixture tainted with diethylene glycol. Diethylene glycol monobutyl ether. About half were receiving Lisinopril (a blood pressure medicine), and many did not remember clearly if they had been taking other drugs. [23][24][25], After recalling millions of wine bottles, the Austrian Government had no idea how to destroy the product. [39] A New York Times reporter tried to obtain a comment from CNSC Fortune Way at the CPhI worldwide (the world’s largest annual pharmaceutical convention) held in Milan, Italy, during 2007, but their representatives refused to comment. diethylene glycol monobutyl ether (English) retrieved. [35] By June 1996, with no idea what was causing the epidemic, the Pan American Health Organization (PAHO) Haiti representative contacted the World Health Organization (WHO, the parent agency of PAHO), and WHO requested that the Centers for Disease Control and Prevention investigate.[36][29][37]. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Whitehouse Station, NJ: Merck & Co; 2006. Details : Ethylene Glycol Monobutyl Ether. diethylene glycol monobutyl ether (English) retrieved. Jean-Claude Bradley Open Melting Point Dataset, NFPA 704: Standard System for the Identification of the Hazards of Materials for Emergency Response, InChI=1S/C8H18O3/c1-2-3-5-10-7-8-11-6-4-9/h9H,2-8H2,1H3, Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard, splash10-006t-9000000000-9b5ce4bf5bfa84239e88, splash10-03di-1900000000-8aef03e0bb456b96d1a4, splash10-03di-0900000000-3ac8a328666dee650638, splash10-0a4j-9000000000-44b0731c3639435643fb, https://www.wikidata.org/w/index.php?title=Q1018210&oldid=1314798026, Creative Commons Attribution-ShareAlike License. Bogdanich, W.; McLean, R. "Poisoned Toothpaste in Panama Is Believed to Be From China". 14th ed. ", "Letter from Bombay. Ethylene glycol is by far the largest volume of the glycol products in a variety of applications. Fourteen patients received hemodialysis, but the treatment failed. [58], In July 2007, health authorities in the UK detected a counterfeit Sensodyne toothpaste on sale at a car boot sale in Derbyshire. Seventeen other persons have also been charged related to this incident. [27], At a hospital in Bombay, India, patients were admitted to be treated for diverse health problems. [44], The New York Times reported that Taixing was closed by the Chinese government and CNSC Fortune Way, which is also owned by the Chinese government, was never sanctioned. The episode resulted in the deaths of 21 patients and the discovery of glycerin contaminated with 18.5% v/v of DEG. [1], DEG is produced by the partial hydrolysis of ethylene oxide. 121; Ethylne glycol butyl ether; Ethylene glycol monobutyl ether; Glycol butyl ether; Monobutyl glycol ether; 3-oxa-1-heptanol; EPA Pesticide Code: 011501 Bogdanich, W. "Toxic Toothpaste Made in China Is Found in U.S. ". [6] It is also a component in brake fluid, lubricants, wallpaper strippers, artificial fog and haze solutions, and heating/cooking fuel. Only 88 children deaths were recalled by doctors or had medical records. Although there is limited information about toxicokinetics in humans, observations in mass poisonings and experimental studies suggest the following information: The principal method of absorption is through oral ingestion. Jump to: navigation, search. [10], Diethylene glycol has moderate acute toxicity in animal experiments. The study revealed a strong association between ingestion of two locally produced acetaminophen liquid products (Afebril and Valodon) and illness. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. The children later developed kidney failure and died. Internal Medicine Residency Program of the College of Medicine of Wake Forest University, North Caroline, U.S.A. [1][7], The symptoms of poisoning typically occur in three characteristic intervals:[1], Fomepizole or ethanol should be quickly administered to prevent diethylene glycol being metabolized to the compound or compounds that cause the real damage.[1]. The regional drug controller authorities after investigation found out that a faulty batch of the Coldbest PC cough syrup contained 34.97% of diethylene glycol, which resulted in poisoning and subsequent renal failures. [3], The physical properties of diethylene glycol make it an excellent counterfeit for pharmaceutical-grade glycerine (also called glycerol) or propylene glycol, and has caused many deaths in different countries. The counterfeit syrup ended in ampules of Amillarisin A, a medication for gall bladder problems; special pediatric enema fluid; blood vessel disease injections; intravenous pain reliever; and an arthritis medication. [39][41], Taixing sold the syrup as “TD glycerin”, wording that neither Chinese inspectors nor Spanish medical authorities comprehended. Tracked Poisoned Drugs, but Trail Went Cold in China", "From China to Panama, a trail of Poisoned Medicine", "Aumentan Envenenados con Dietilene Glycol", "Outbreak of acute renal failure in Panama in 2006: a case-control study", "Caso dietilene glycol puede viciarse: Troitiño", "24 Niños afectados por utilización de tóxico", "Rasfer Internacional se declara en bancarrota", "Panamá bloquea el proceso español por el caso del jarabe asesino", Guidance for Industry – Testing of Glycerin for Diethylene Glycol, "China investigating toothpaste containing potentially deadly chemical", "U.S. checking all toothpaste imports from China", "7online.com: Toothpaste recall expands 6/18/07", "The Everyman Who Exposed Tainted Toothpaste", News.yahoo.com Nigeria child deaths from tainted syrup rise to 84, Nigeria child deaths from tainted syrup rise to 84, "84 Children Are Killed by Medicine in Nigeria", NAFDAC Negotiates State of the art Anti Counterfeiting Equipment, "Laudo da Polícia Civil aponta que cerveja adulterada causou doença misteriosa em BH", "Polícia confirma 3ª morte por síndrome nefroneural", "Ministério da Agricultura identifica contaminação em oito rótulos de cervejas da Backer", "Morre 10ª vítima por intoxicação de cerveja da Backer", "Behind killer cough syrup Coldbest: Glaring gaps in regulation and its manufacture", "J&K children deaths: Kids consumed cough syrup with poisonous chemical, probe reveals", https://en.wikipedia.org/w/index.php?title=Diethylene_glycol&oldid=998487761, Articles with dead external links from July 2019, Articles with permanently dead external links, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles containing Chinese-language text, Creative Commons Attribution-ShareAlike License, 244 to 245 °C (471 to 473 °F; 517 to 518 K), This page was last edited on 5 January 2021, at 16:24. English: Structure of Diethylene glycol monobutyl ether acetate. The prognosis depends on prompt diagnosis and treatment due to the high mortality rate DEG intoxication produces. [29] The United States Food and Drug Administration also issued an Industry Guidance Document “intended to alert pharmaceutical manufacturers, pharmacy compounders, repackers, and suppliers to the potential public health hazard of glycerin contaminated with diethylene glycol (DEG)” and recommended appropriate testing procedures for the use of glycerin. From CAMEO. [3], "Diethylene glycol is derived as a co-product with ethylene glycol (MEG) and triethylene glycol. [11] In the case of DEG, observations demonstrated there were no calcium oxalate crystal deposits in the kidneys, implying ethylene glycol is not on the DEG metabolic pathway. Reuter. Alibaba.com offers 101 diethylene glycol monobutyl ether products. [14][15], In 1937, S.E. 9TB90IYC0E. [32][33][34], In the poorest country in the Western Hemisphere, disease outbreaks are not recognized unless widespread or unusual. Following restrictive measures decided by one Member State on the basis of Article 12 of Directive 76/768/EEC regarding the use of diethylene glycol monobutyl ether (DEGBE) and ethylene glycol monobutyl ether (EGBE) in cosmetic products, the SCCP was consulted. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. Once he was inside, there was nothing to do: the plant had already been shut down. Bureau of Alcohol, Tobacco, and Firearms. Hemodialysis might be administered alone or with ethanol or fomepizole. [40] Two months later, findings revealed that 145 were proven to die by DEG intoxication, but the DA still has to investigate 953 demands. The ether being relatively unreactive. This page was last edited on 28 November 2020, at 22:06. The symptoms seemed to match with Guillain–Barré syndrome, but these patients were also losing their ability to urinate, a symptom not related to Guillain–Barré. These measures quickly ended the advance of the epidemic. [31], A propolis syrup manufactured by Huilen Laboratories in Buenos Aires, Argentina, contained between 24 and 66.5% DEG, and caused the death of 29 people. With the available technology of the era, the CDC determined the glycerin used in the syrup preparation was contaminated with approximately 24% DEG. [70] The investigation revealed that DEG had been used as a coolant for the brewery equipment, in what should have been a closed circuit, but an undetected leak in the system contaminated some batches of beer. I, the copyright holder of this work, hereby publish it under the following licenses: of morpholine and 1,4-dioxane. All patients are likely to suffer significant morbidity. It was assumed that DEG was used as a substitute of propylene glycol, and this incident encouraged the Nigerian government to develop pharmaceutical quality control guidelines. ", "Scandal over poisoned wine embitters village in Austria.". [70] On 18 July, the 10th victim died in a Belo Horizonte hospital, a 65-year-old man who had been hospitalized since December 2019 due to the poisoning. They identified Tianhong Fine Chemicals Factory as the manufacturer. Promotes uniform dispersion; translucent to clear. AICS Chemical ID. [1][19][29][30], In Bangladesh between 1990 and 1992, 339 children developed kidney failure, and most of them died, after being given paracetamol (acetaminophen) syrup contaminated with diethylene glycol. They also arrested 12 people in connection with the incident. The factory of the medication manufacturer, Pharval, was subsequently investigated by Dr. Joel Selanikio (also of CDC, and an Epidemic Intelligence Service classmate of Katherine O'Brien). stated in. They react with oxoacids and carboxylic acids to … [47], During June 2011, the number of confirmed deaths according to the official list rose to 219 victims [48], In May 2007, a Panamanian named Eduardo Arias discovered a 59-cent toothpaste that was labeled containing DEG. U.S. Food and Drug Administration Press Release. [1][19][28], During the summer months, 47 children were admitted to the Jos University teaching hospital, Nigeria, with anuria, fever and vomiting. Records also revealed that to fool buyers, Wang falsified his license and laboratory analysis reports. The industry generally operates to maximize MEG production. The outbreak forced the government to ban the sale of paracetamol elixirs in December 1992, causing a decline of 53% in the admission of patients with kidney failure and an 84% decline in admissions by unexplained kidney failure. [67] On 17 January, the police confirmed the fourth death from symptoms matching DEG poisoning, and DEG contamination had been found in eight brands of beer from the same brewery. Unique Ingredient Identifier. [42], In August 2009, the Supreme Court decided to send the diethylene glycol file to the Public Ministry for an extension. Bogdanich, W. "Wider Sale Is Seen for Toothpaste Tainted in China ", U.S. Bureau of Alcohol, Tobacco and Firearms, Centers for Disease Control and Prevention, "Toxic alcohol ingestions: clinical features, diagnosis, and management", ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN: Polyethylene glycol, Existing Chemical Hazard Assessment Report, Australian Competition and Consumer Commission, "Toothpaste containing more than 0.25 per cent by weight of diethylene glycol (DEG)". A dilute solution of diethylene glycol can also be used as a cryoprotectant; however, ethylene glycol is much more commonly used. It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. It is a humectant for tobacco, cork, printing ink, and glue. At the request of the United States, the State Food and Drug Administration of China investigated Taixing Glycerine Factory and CNSC Fortune Way, but the agency concluded it is not under their jurisdiction because the factory is not certified to make medicine. Description. DIETHYLENE GLYCOL MONOBUTYL ETHER 9TB90IYC0E Overview Structure Names 10: Classification 1: Identifiers 9: Relationships 1: Active Moiety 1: Audit Info References 15: Moieties 1: Substance Class: Chemical Record UNII: 9TB90IYC0E. It is a solvent for nitrocellulose, resins, dyes, oils, and other organic compounds. Fill out the form below and we will be in touch shortly. U.S. Food and Drug Administration Press Release. Diethylene Glycol Monobutyl Ether poisoning symptoms, causes, diagnosis, and treatment information for Diethylene Glycol Monobutyl Ether poisoning (Chemical poisoning - Diethylene Glycol Monobutyl Ether) with alternative diagnoses, full-text book chapters, misdiagnosis, research … After manufacturing a second batch of syrup containing diethylene glycol for Qiquhar Pharmaceutical, no taste-test was performed. The primary results revealed that the mixture was more effective than using salt alone. A series of solvents used for oils, resins, gums and many polymers that is sold commercially under the name Carbitol. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. Draw with ChemBioDraw Ultra 12.0. UNII. Postmortem examination revealed damage in the kidneys and liver, and laboratory testing found DEG instead of propylene glycol in the sedatives. [53][54] Days later, Colgate-Palmolive found counterfeit toothpaste with its name, which was contaminated with DEG and found at dollar-type discount stores in New York, New Jersey, Pennsylvania and Maryland. Butyl di glycol (also known as BDG, butyl dioxitol, diethylene glycol monobutyl ether, 2(-2butoxyethoxy) ethanol and butoxydiethylene glycol) is a colourless, clear organic compound with a faint characteristic odour that has the formula C 8 H 18 O 3.It is soluble in water and miscible with many common solvents, and also has low volatility and a high boiling point. [19] This law, though extensively amended in subsequent years, remains the central foundation of FDA regulatory authority to the present day. 9TB90IYC0E. It was not until September 1996 that Sinochem provided a name of the manufacturer of the tainted syrup. DIETHYLENE GLYCOL MONOBUTYL ETHER 9TB90IYC0E Overview Structure Names 9: Classification 1: Identifiers 9: Relationships 1: Active Moiety 1: Audit Info References 15: Moieties 1: Substance Class: Chemical Record UNII: 9TB90IYC0E. One year and a half after the FDA began to trace the poisonous shipments, an inspector, Ted Sze, finally visited the Tianhong Fine Chemicals Factory in Dalian, northeastern China. Doctors prescribed glycerine for its osmotic diuretic effect, but patients started to develop kidney failure. CARBITOL Solvent. [64][65][66], In December 2019, some people in the city of Belo Horizonte, initially all from the same neighbourhood, started having symptoms such as nausea, vomiting, abdominal pain, acute kidney failure, facial nerve paralysis, blurred vision, temporary blindness and sensory changes. What began as a local alert revealed a global problem in more than 30 countries and involving more than thirty brands. They react with oxoacids and carboxylic acids to … [3] Lead CDC investigator Dr. Katherine O'Brien conducted a case-control investigation, looking for potential clues to the epidemic. Depending on the conditions, varying amounts of DEG and related glycols are produced. [57] It was later discovered that a great number of tubes with poison ended up in hospitals for the mentally ill, prisons, juvenile detention centers, other hospitals and many other state institutions. The metabolites were determined in the urine. 45 Austrian, 5 German and 12 Italian wines tested positive for DEG. CS1 maint: multiple names: authors list (. Dermal absorption is very low, unless it is administered on broken or damaged skin. Mr. Wang was caught and Qiquihar was shut down by the authorities. It is a clear liquid with a very low odor and high boiling point. The fiscal attorney urged affected citizens to approach the Public Ministry to update the official legal file and for further medical analysis. [40] The 46 barrels of syrup were bought by Social Security Laboratories through a Panamanian middleman, Grupo Comercial Medicom, who bought the product from Rasfer Internacional, a Spanish company. [52], On June 1, 2007, the FDA warned consumers to avoid toothpaste from China, although there was no information if these toothpastes had already entered the US, and started testing any imported Chinese toothpaste. [55][56] Although there were no reports of anyone harmed, several people in the eastern US reported experiencing headaches and pain after using the product. In numerous epidemics of poisoning since the early 20th century acute toxicity animal..., he shipped it to Qiquihar no monobutyl ether ( DEGBE ) is produced by the authorities `` Colgate... Counterfeit Colgate Toothpaste found '', June 1, 2 ] the conditions varying!, present as an byproduct of ethylene glycol is by far the largest volume the! 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